Monogagaine, a Novel Dimeric Indole Alkaloid from Tabernaemontana chippii and Tabernaemontana dichotoma [1]
نویسندگان
چکیده
Tabernaemontana chippii and Tabernaemontana dichotoma [1] Teris A. van Beek*, Peter P. Lankhorst, Robert Verpoorte, Georges Massiot, Roel Fokkens, Cornelis Erkelens, Premila Perera, and Cecilia Tibell a Department of Pharmacognosy, Gorlaeus Laboratories, P .O.Box 9502, 2300 R A Leiden, The Netherlands b Depar tment of Organic Chemistry, Leiden, The Netherlands c Faculte de Pharmacie, Reims, France d Labora tory of Organic Chemistry, Amsterdam, The Netherlands e Department of Pharmacognosy, Uppsala, Sweden
منابع مشابه
Cytotoxic vobasine, tacaman, and corynanthe-tryptamine bisindole alkaloids from Tabernaemontana and structure revision of tronoharine.
Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed appreciable cytotoxicity toward KB cells (IC50 ca. 5 μg/mL). The structure of the known Tabernaemon...
متن کاملIsolation of bis-indole alkaloids with antileishmanial and antibacterial activities from Peschiera van heurkii (syn. Tabernaemontana van heurkii).
Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Arg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with...
متن کاملA Concise and Versatile Double Cyclization Strategy for Highly Stereoselective Synthesis and Novel Arylative Dimerization of Aspidosperma Alkaloids**
The monoterpene indole alkaloids represent the largest family of alkaloid natural products whose more than 2,000 members display a broad range of chemical diversity and potent biological activity.1 The structural challenges presented by this family have long been a source of interest, resulting in the development of a variety of inventive synthetic strategies to access various family members. T...
متن کاملA New Natural Quaternary Indole Alkaloid Isolated from Tabernaemontana laeta Mart. (Apocynaceae)
Um novo alcalóide quaternário natural, N b -metilvoachalotina (1), três alcalóides indólicos diméricos, conodurina (2), voacamina (3) e tabernamina (4), e os três alcalóides monoméricos 19S-heyneanina (5), coronaridina (6) e voacangina (7) foram isolados da casca das raízes de Tabernaemontana laeta. Os triterpenos conhecidos 3-O-acetil-amirina, 3-O-acetil-amirina, 3-O-acetil-lupeol e 3-O-acetil...
متن کاملStudies on the pharmacology of conopharyngine, an indole alkaloid of the voacanga series.
Conopharyngine, the major alkaloid present in the leaves of Tabernaemontana (Conopharyngia) pachysiphon var. cumminsi (Stapf) H. Huber was isolated and identified by Thomas & Starmer (1963). The same alkaloid has also been found in the stem bark of a Nigerian variety of the same species by Patel & Poisson (1966) and in the stem bark of Conopharyngia durissima by Renner, Prins & Stoll (1959). Co...
متن کامل